University Medical Center Rostock

We are the main ALS centre in Mecklenburg offering primary diagnostics, secondary opinion, genetic testing, patient care and individualized therapy for all stages of ALS, including also care in advanced stages including NIV/IV and nutrition. We have inpatent and outpatient clinics, caring for ~100 patients per year. Our expertise ranges from deep phenotyping of patients including cognitive and behavioral endophenotypes, (molecular) imaging and biomarker research to basic research on patient-derived cell models. A main focus of the working group is the bidirectional translation between basic science and clinical patient work, including human patient-derived iPSC cultures, drug development, biomarker development (wet markers, MRI markers, PET markers and behavioral endophenotypes);. Future direction will more and more involve work on healthy and diseased aging including modes and mechanisms of disease conversions from prodromal stages or interventions to avoid secondary aging. We are part of national (MND-NET, DZNE) and international registries (Precision-ALS). We take part in diverse clinical studies including interventional and non interventional prospective clinical trials.