Johnathan Cooper-Knock, dr.
Consultant Neurologist
Amyotrophic lateral sclerosis (ALS) is an urgent health need and an archetypal complex disease determined by the interaction of multiple genetic and environmental factors. Johnathan has shaped his career to address ALS and move towards personalized interventions. His background is in genetics and his lab was the first to describe non-coding genetic risk factors for ALS in a significant proportion of patients; moreover, they have recently increased the number of ALS risk genes by an order of magnitude through new machine-learning analysis. The central aim of his approach is to achieve personalized medicine for ALS through subdivision of patients according to their own specific genetic and environmental disease-determinants. As a result his lab have pioneered the application of Mendelian randomization (MR) for discovery of environmental risk factors for ALS including the development of new methodology.
Location
University of Sheffield
Glossop Road, S10 2JFSheffieldUnited Kingdom